School of Computer & Communication Sciences [Only registered and activated users can see links. ]
Lausanne, January 25, 2010
The School of Communication and Computer Sciences at
Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland
together with the
Novartis Institute for BioMedical Research (NIBR), Basel, Switzerland
is inviting applications for a postdoctoral fellow in the field of
Computational Drug-Target Identification.
The position is funded by the Swiss Initiative in Systems Biology (SystemsX.ch) and is hosted by the systems biology group of Dr. Koeppl at the Laboratory of Nonlinear Systems, EPFL. Goal of this interdisciplinary project is to assess the feasibility and performance of rule-based modeling approaches for applied pathway modeling and for in silico drug intervention analysis. The case study considered is the
TOR (Target of Rapamycin) signaling pathway in yeast and mammals. Planned steps are – (1)
documentation of known TOR-pathway-related events in a formal and executable representation utilizing
rules, (2) equipping those rules with kinetics through literature mining, dedicated measurements and
calibration algorithms and finally (3) validating the rule-based description in perturbation scenarios and
identifying optimal intervention points through a generalized sensitivity analysis.
We are seeking outstanding candidates with a firm mathematical and computational background as well
as experience in dynamical modeling of biochemical reaction networks. The candidate may hold a Ph.D.
degree in computer science, applied mathematics, physics, electrical engineering, bioinformatics or
biochemistry. The position will initially be filled for one year and is extendable upon positive evaluation.
The yearly gross salary amounts to CHF 90k. Candidates should send their publication list and CV
including at least three references per email (in pdf) to:
Dr. Heinz Koeppl
Email: [Only registered and activated users can see links. ]
Laboratory of Nonlinear Systems
School of Communication and Computer Sciences
Ecole Polytechnique Federale de Lausanne (EPFL)
Tel.: +41 21 693 2734
Application deadline: 21.02.2010 (although applications will be considered until the position is filled)
LABORATORY OF NONLINEAR SYSTEMS (LANOS)
EPFL IC ISC LANOS
Dr. Heinz Koeppl
Building BC
Station 14
CH-1015 Lausanne, Switzerland
Phone :
Secretariat
Fax :
E-mail :
Website :
+4121 693 2734
+4121 693 2656
+4121 693 6700
[Only registered and activated users can see links. ]
[Only registered and activated users can see links. ]